The hotel features 161 rooms and suites, including the WOW Bohemia Duplex, along with a W Lounge and a panoramic rooftop bar. The design of W Prague was created by the architectural firms Benoy, AvroKO, and Chapman Taylor, who seamlessly integrated the Art Nouveau elements of the historic building with a new nine-story contemporary wing designed by the DAM studio. The concept "Elixir", blending tradition and innovation, is reflected throughout the hotel's architecture and spaces.

The "Jardin Fantastique", a corridor adorned with a trompe-l'œil embroidery inspired by Alphonse Mucha, complements the lighting installations created by Preciosa Lighting. The hotel also showcases artworks by local and international artists.

W Prague offers a diverse culinary experience, including Riccardo Giraudi's Petit Beefbar, the W Lounge serving cocktails and tapas, the Above Rooftop bar on the roof, and the intimate Bisou bar.

The AWAY spa features a WET pool, sauna, hammam, and wellness treatments, including the signature De-Stress massage. The FIT gym is equipped with modern equipment and offers on-demand fitness classes.